Reticulohistiocytosis

Reticulohistiocytosis disease is also referred to as lichen myxedematosus or scleromyxedema. Pink to skin-colored papules that are firm, 2 to 5 mm in diameter, and often in a linear arrangement are seen in patients with papular mucinosis.

Symptoms of Reticulohistiocytosis

Patients with multicentric reticulohistiocytosis also have pink-colored papules and nodules on the face and mucous membranes as well as on the extensor surface of the hands and forearms. They have a polyarthritis that can mimic rheumatoid arthritis clinically.

Diagnosis of Reticulohistiocytosis

On histologic examination, the papules have characteristic giant cells that are not seen in biopsies of rheumatoid nodules. The latter name comes from the brawny induration of the face and extremities that may accompany the papular eruption.

Biopsy specimens of the papules show localized mucin deposition, and serum protein electrophoresis demonstrates a monoclonal spike of IgG, usually with a l light chain

Amyloidosis
Connective tissue naevi
Dermatofibroma
Dermatofibrosarcoma protuberans
Ehler's Danlos syndrome
Elastosis perforans serpiginosa
Keloids & hypertrophic scars
Lipodystrophy
Lipoma
Mastocytoma
Neurofibroma
Pseudoxanthoma elasticum
Reactive perforating collagenosis
Striae (stretch marks)
Eosinophilic fasciitis
Erythema multiforme
Histiocytoses
Jessner's lymphocytic infiltrate
Langerhans cell histiocytosis
Lymphocytoma cutis
Lymphomatoid papulosis
Mastocytosis
Morphoea
Non-Langerhans cell histiocytosis
Panniculitis
Reticulohistiocytosis
Sweet's disease
Systemic sclerosis
Atypical mycobacterial infection
Granuloma faciale
Granuloma annulare
Cutaneous tuberculosis
Leprosy
Pyogenic granuloma
Sarcoidosis