Elastosis perforans serpiginosaseElastosis perforans serpiginosa (EPS) is a uncommon skin disease in which abnormal elastic tissue fibre passes from the inner layer of skin to the epidermis - the outer layer of skin. This disease looks like a group of small reddish bumps. At any time, even after years of uneventful penicillamine administration, granulocytopenia, thrombocytopenia, the nephrotic syndrome, Goodpasture's syndrome, systemic lupus erythematosus, severe arthralgias, myasthenia, mammary gigantism, or elastosis perforans serpiginosa may supervene. Except for transient thrombocytopenia or granulocytopenia, these reactions mandate the replacement of penicillamine with trientine. Although the only reported toxic reaction to trientine is sideroblastic anemia, the same clinical procedures and laboratory determinations should be performed during its administration as are used during penicillamine therapy. Except for systemic lupus erythematosus and, occasionally, elastosis perforans serpiginosa, the other late penicillamine-induced toxic reactions disappear or improve with trientine therapy. Moreover, trientine is as effective therapeutically as penicillamine. Who gets Elastosis perforans serpiginosaEPS is more 4 times commom in males than females. Commonly it appears during early adulthood (20-30 years) but may been seen in early childhood or late in life. Treatment for Elastosis perforans serpiginosaThere is no cure for EPS. Usually it spontaneously resolves without complications after a few years. |
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