Metaprolol

What is the use of Metaprolol and how it works?

It is the prototype of Cardio Selective (Beta 1) blockers. Its potency to block cardiac stimulation is similar to propranolol and is less likely to worsen asthma, but not entirely safe. it may also be preferred to propranolol in diabetics receiving insulin or oral hypoglycaemics.

Indications of Metaprolol

Hypertension, angina pectoris, acute myocardial infarction.

Dosage of Metaprolol

Adults: 100-200 mg in two divided doses.
Children: 1-5 mg/kg/day in two divided doses.

Contracdictions of Metaprolol

Bradycardia, cardiogenic shock, 2nd or 3rd degree A.V. block, cardiac failure. Verapamil therapy. Br. Asthma/COPD.

Precautions of Metaprolol

General anaesthesia, pregnancy, reduced cardiac reserve, C.C.F.
Paediatrics: Reduced dose necessary.
Pregnancy: May effect the foetus.
Lactation: May pass in breast milk. Hence use only if clearly indicated.
Elderly: Reduce the dose, if necessary.

Drug Interactions of Metaprolol

Cimetidine potentiates metoprolol. Negative ionotropic effect with general anaesthetics. Bioavailability increased by food. Enancement of antihypertensive effect with diuretics and vasodialators. useful combination with digitalis.

Side effects of Metaprolol

Headache, nightmares, hypotension, eye and skin reactions, bradycardia.

Drug A-Z Index

Digoxin
Propranolol
Metaprolol
Atenolol