Atenolol

What is the use of Atenolol and how it works?

it is a relatively cardio selective Beta-andrenoceptor blocking agent without membrane stabilizing or intrinsic sympathomimetic activities. Following oral doses of 50 or 100 mg, both Beta-blocking and antihypertensive effects persists for at least 24 hours because of higher lipid solubility.

Indications of Atenolol

Hypertension, angina pectoris, acute myocardial infarction.

Dosage of Atenolol

Adults: 50-100 mg daily.
Children: 1-1.3 mg/kg/day daily or two divided doses.

Contracdictions of Atenolol

Sinus bradycardia, heart block greater than first degree, cardiogenic shock overt cardiac failure, anuria or known hypersensitivity reaction to atenolol and/or nifedipine (in case of combinations).

Precautions of Atenolol

Renal Impairment, pregnancy, diabetes, untreated cardiac failure, sudden withdrawl may exacerbate angina pectoris and may precipitate M.I. anaesthetic agents may further cause depression of myocardium. Myocardial contractility.
Paediatrics: Not recommended.
Pregnancy: No risk factor.
Lactation: Present in breast milk.
Elderly: No special problem.

Drug Interactions of Atenolol

With verapamil precipitation of heart failure. Simultaneous withdrawl of Atenolol and Clonidine result in rebound hypertension. Indomethacin reduces antihypertensive effect.

Side effects of Atenolol

Bradycardia, cold extremities, leg pain, dizziness, tiredness, fatigue and lethargy, skin rashes and/or dry eyes.

Drug A-Z Index

Digoxin
Propranolol
Metaprolol
Atenolol